EMITOG - Exploring MITOchondrial Transfer as a Novel Geroprotective Paradigm-
Deadline: 13/03/2026
Scientific-Disciplinary Group
05/BIOS-06 - Physiology
Description
Aging undermines the body's ability to adapt, particularly the function of thermogenic adipose tissue (t-AT), which is essential for metabolism. As we age, the quality of mitochondria declines, leading to metabolic disorders like insulin resistance and type 2 diabetes.When adipocytes are stressed, they release damaged mitochondria that are quickly cleared by macrophages. These immune cells transform into "M2" macrophages, which have anti-inflammatory properties. Recent discoveries indicate that M2 macrophages can transfer their healthy mitochondria to adipocytes, providing bioenergetic support.The hypothesis is that with aging, this virtuous cycle is disrupted, accelerating metabolic decline and aggravating age-related diseases
Job posting website
Number of positions
1
Funding body
Università degli Studi di Roma Tor Vergata- Dipartimento di Biologia
View the original posting on the MUR website: Go to MUR website