Overcoming Cancer Drug Resistance Through Metabolism-Based Pharmacology (One – Health Sciences and Technologies No. 29: New Therapeutic Strategies)
Posted on: 11/03/2026
Deadline: 26/03/2026
Scientific-Disciplinary Group
06/MEDS-02 - Experimental Medicine, Pathophysiology And Clinical Pathology
Description
This research project aims to investigate the potential repurposing of certain drugs, such as ivermectin, metronidazole, and OXPHOS-activating compounds such as honokiol, methylene blue, and lactoferrin, to make drug-resistant tumor cells more sensitive by reversing the Warburg effect and the redox potential of these cells, with potential therapeutic implications. Our approach, which combines synergistic methods that target multiple metabolic pathways (3-4), aims to regulate the metabolism of drug-resistant tumor cells to make them more sensitive. By inhibiting fermentative and anabolic processes and regulating the redox potential, this strategy will help reverse the aggressive tumor phenotype and increase drug sensitivity in drug-resistant cells.
Job posting website
https://reclutamento.ict.uniba.it/contratti-di-ricerca/concorsi/2026-ctr.01
Number of positions
1
Funding body
Università degli studi di Bari
How to apply
Other
View the original posting on the MUR website: Go to MUR website