CdR17/26 Investigation of ferroptosis and metabolic rewiring in pancreatic cancer models

Position: Post-doctoral research contract Institute: Uni. Verona
Posted on: 30/04/2026 Deadline: 25/05/2026

Scientific-Disciplinary Group

05/BIOS-07 - Biochemistry

Description

This project, funded under the FIS3 call, aims to develop innovative therapeutic strategies for pancreatic ductal adenocarcinoma by inducing ferroptosis and targeting tumor metabolic vulnerabilities. In particular, it will investigate the activity of CO-APR-246, a novel carbon monoxide-releasing molecule (CORM) derived from APR-246, alongside a first-in-class PFKFB3 inhibitor, evaluating their individual and synergistic anti-tumor effects. Through the integration of multi-omics approaches and in vivo models, the project will dissect the molecular mechanisms underlying treatment response and resistance. Ultimately, these findings will support the development of a predictive model for patient stratification and the identification of more effective, personalized therapeutic strategies.

Compensation

28,456 Euro

Job posting website

https://www.univr.it/it/concorsi/contratti-e-assegni-di-ricerca/contratti-di-ricerca/0/16109

Number of positions

1

Maximum duration

24.0

Funding body

Università degli Studi di Verona

How to apply

Other

Selection process

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The competition will be carried out by an evaluation of titles and examination by means of an interview. For admission to the selection process referred to in Art. 1, potential candidates must fulfil the following requirements:a) Title of Phd in the biomedical area, namely to be enrolled in the third year of doctoral studies, as long as the achievement of the qualification is planned within the six months following the date of publication of the announcement for application;b) Possession of a curriculum suitable for assisting in carrying out research activities;c) Knowledge of the following foreign language: English;d) Knowledge of the Italian language, level B2 (for fireing citizens).

View the original posting on the MUR website: Go to MUR website

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