CdR20/26 - Characterization of the molecular mechanisms of ferroptosis and metabolic vulnerabilities in pancreatic ductal adenocarcinoma
This project aims to develop innovative therapeutic strategies for pancreatic ductal adenocarcinoma (PDAC) by exploiting ferroptosis induction and the metabolic vulnerabilities that characterize this malignancy. The study will focus on CO-APR-246, a novel carbon monoxide-releasing molecule (CORM) derived from APR-246, a first-in-class investigational drug capable of reactivating mutant p53 and restoring its tumor suppressor function. Furthermore, by integrating multi-omics approaches with in vivo experimental models, the project will investigate the molecular mechanisms underlying therapeutic response and the development of treatment resistance. The knowledge gained will support the development of a predictive model for patient stratification, ultimately enabling the identification of more effective and personalized therapeutic strategies.
Selection process
The competition will be carried out by an evaluation of titles and examination by means of an interview.
For admission to the selection potential candidates must fulfil the following requirements:a) Hold a PhD degree in a biomedical field, or be enrolled in the third year of a PhD programme, provided that the degree is expected to be awarded within six months from the date of publication of this call for applications;b) Possess a scientific and academic curriculum vitae suitable for the research activities envisaged under this call;c) Proficiency in English;d) Proficiency in the Italian language at B2 level for foreign applicants;e) Additional requirements:- experience of a research or academic stay abroad for a minimum period of six months;- at least five years of documented research experience in the scientific field BIOS-07/A – Biochemistry;- supervision of students undertaking research internships and/or undergraduate or master's degree theses;- participation in national and international conferences with oral presentations.