Identification of novel cardiokines regulating systemic diurnal metabolism in heart failure (ref. DR 003/2026)
Scientific-Disciplinary Group
05/BIOS-07 - Biochemistry
Description
The project aimes at defining the secretome of a healthy and diseased heart and to investigate how these secreted molecules impact systemic circadian metabolism in heart failure. To this end, we will employ a cardiomyocyte-specific, in vivo labeling approach, allowing for the labeling, enrichment, and identification of proteins secreted by the heart during pathological cardiac hypertrophy. The identified cardiomyocyte-secreted factors will be functionally screened in vitro and then in vivo via AAV9 mediated cardiac-specific overexpression of selected candidates, followed by metabolic phenotyping.
Compensation
22,500 Euro
Job posting website
Number of positions
1
Funding body
HUMANITAS UNIVERSITY
View the original posting on the MUR website: Go to MUR website