AIRC IG, Rif. 27350 - Role of the gut microbiome in the outcome of diffuse large B-celllymphomapatientstreated with CAR-T cell therapy
Deadline: 18/02/2026
Scientific-Disciplinary Group
03/CHEM-07 - Medicinal, Toxicological, Nutraceutical-Food, Fermentation And Health And Wellbeing Products Chemistry
Description
Sample Centralization and Analysis In continuation of last year’s work, I centralized new biological samples from recently enrolled patients, tracking, storing, and recording them at the Human Microbiomics Unit. Fecal DNA was extracted and the V3–V4 region of 16S rRNA sequenced to profile gut microbiota diversity. For 132 previously collected samples, high-depth metagenomic shotgun sequencing was performed, with quality control and preprocessing. Bioinformatic pipelines enabled species- and strain-level profiling and reconstruction of patient-specific bacterial genomes (MAGs). Functional analyses identified potential gene drivers related to clinical outcomes, focusing on metabolic pathways and antibiotic resistance genes.
Job posting website
Funding body
ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE
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