Deciphering the causal role of metabolome in metabolic syndrome
Deadline: 21/03/2026
Scientific-Disciplinary Group
06/MEDS-26 - Methods in Laboratory Medicine, Technical Diagnostic, Assistance, Prevention And Rehabilitation Health Profession Sciences, Advanced Medical And Surgical Technology And Methodology
Description
Metabolic Syndrome is composed by 4 major components: dysglycemia (impaired tolerance and impaired fasting glucose), hypertension, increased visceral adiposity and dyslipidemia (increased triglycerides and low hdl cholesterol). To gain a mechanistic understanding of how the gut microbiota affects host metabolism joint analyses of high-throughput human multi-omics data, including metagenomics and metabolomics data, together with measures of host physiology and mechanistic experiments in humans and cells will be performed to identify potential molecular mechanisms behind reported associations. The overarching hypothesis of this research proposal is that the human metabolome can capture the pathophysiological basis of metabolic syndrome. It is further hypothesized that microbial metabolites serve in part as the causal mediators of the etiology of tissue dysfunction in subjects with metabolic syndrome
Job posting website
Number of positions
1
Funding body
Università degli Studi di Roma Tor Vergata- Dipartimento di Medicina dei Sistemi
View the original posting on the MUR website: Go to MUR website