Novel Avenanthramide Derivatives as Muco-Protective Agents in Cancer Therapy-Induced Oral Mucositis

Position: Research appointment (pre-doc) Institute: Uni. Turin
New! Posted on: 19/03/2026 Deadline: 09/04/2026

Scientific-Disciplinary Group

06/MEDS-09 - Blood Diseases, Oncology And Rheumatology

Description

Oral mucositis (OM) is one of the most common inflammatory complications in cancer patients. The onset of OM often requires a reduction in dosage or suspension of antineoplastic therapy, highlighting the urgent need for effective preventive and therapeutic strategies. Avenanthramides have been shown to have protective effects on epithelial tissues, but their limited use is due to poor bioavailability. The project aims to elucidate the mucoprotective properties of synthetic avenanthramide derivatives (XX-AVE) previously selected as ideal candidates due to their high bioavailability. In the first phase, the mucoprotective effects of XX-AVE will be estimated using in vitro cell models composed of SG and MUR oral lines. Subsequently, the most effective compounds will be analyzed using advanced proteomic approaches in order to identify the molecular pathways involved in their mucoprotective activity.

Compensation

22,500 Euro

Job posting website

https://lavorainateneo.unito.it/index_ir.html?type=SEL_IDR

Number of positions

1

Maximum duration

12.0

Funding body

Università di Torino

How to apply

https://pica.cineca.it/unito/medoc-2026-ii/

Selection process

Click to expand
Based on Qualifications and Interview. The interview schedule is published on the University Albo ( https://webapps.unito.it/albo_ateneo/ ) and on the University website ( https://lavorainateneo.unito.it/index_ir.html?type=SEL_IDR ). Candidates will NOT receive notification of their admission to the interview. The publication of the schedule on the University Albo constitutes legal notification of the interview invitation. Applications must be submitted via the online procedure https://pica.cineca.it/unito/medoc-2026-ii/ — for information: incarichiricerca@unito.it Mandatory requirement for admission to the selection: italian Laurea Magistrale, or Laurea a Ciclo Unico, or an equivalent degree from foreign Universities, obtained no more than 6 years prior to the application deadline (i.e obtained after April 9, 2020). The Call for Applications (published on the University Bulletin Board under ref. no. 2723 del 19/03/2026), containing the procedures to participate in the selection process and the specific requirements for each selection, is available at https://webapps.unito.it/albo_ateneo/ and https://lavorainateneo.unito.it/index_ir.html?type=SEL_IDR .

View the original posting on the MUR website: Go to MUR website

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