Revealing the role of tumor-educated platelets in cancer: insights into thrombosis, metastasis and? therapy?

Position: Research appointment (pre-doc) Institute: Uni. Turin
New! Posted on: 19/03/2026 Deadline: 09/04/2026

Scientific-Disciplinary Group

05/BIOS-09 - Clinical Biochemistry And Clinical Molecular Biology, 05/BIOS-10 - Cellular And Experimental Biology, 06/MEDS-05 - Internal Medicine, 06/MEDS-09 - Blood Diseases, Oncology And Rheumatology

Description

Cancer-associated thrombosis (CAT) increases the risk of blood clots in cancer patients and contributes to metastasis through complex interactions involving endothelial dysfunction, platelet activation, inflammation, and hypercoagulation. This study investigates how lung cancer reshapes the tumor microenvironment into a pro-thrombotic and pro-metastatic niche, focusing on mitochondrial reprogramming driven by aberrant NF-kB/IkB-alpha signaling. These metabolic alterations promote endothelial activation, platelet conversion into tumor-educated platelets (TEPs), and increased von Willebrand factor release. Using in vitro and in vivo models, the project will examine platelet–tumor interactions, identify specific platelet signatures, and assess the therapeutic potential of targeting TEPs. The findings aim to uncover biomarkers and novel strategies to counteract thrombosis and metastasis in lung cancer patients.

Compensation

22,500 Euro

Job posting website

https://lavorainateneo.unito.it/index_ir.html?type=SEL_IDR

Number of positions

1

Maximum duration

24.0

Funding body

Università di Torino

How to apply

https://pica.cineca.it/unito/medoc-2026-ii/

Selection process

Click to expand
Based on Qualifications and Interview. The interview schedule is published on the University Albo ( https://webapps.unito.it/albo_ateneo/ ) and on the University website ( https://lavorainateneo.unito.it/index_ir.html?type=SEL_IDR ). Candidates will NOT receive notification of their admission to the interview. The publication of the schedule on the University Albo constitutes legal notification of the interview invitation. Applications must be submitted via the online procedure https://pica.cineca.it/unito/medoc-2026-ii/ — for information: incarichiricerca@unito.it Mandatory requirement for admission to the selection: italian Laurea Magistrale, or Laurea a Ciclo Unico, or an equivalent degree from foreign Universities, obtained no more than 6 years prior to the application deadline (i.e obtained after April 9, 2020). The Call for Applications (published on the University Bulletin Board under ref. no. 2723 del 19/03/2026), containing the procedures to participate in the selection process and the specific requirements for each selection, is available at https://webapps.unito.it/albo_ateneo/ and https://lavorainateneo.unito.it/index_ir.html?type=SEL_IDR .

View the original posting on the MUR website: Go to MUR website

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