Monitoring of anti-infective therapy: biomarkers, omics, molecular markers, and monitoring of antimicrobial drug concentrations in blood, cells, tissues in fragile, critically ill, and immunocompromised patients
Scientific-Disciplinary Group
06/MEDS-10 - Gastrointestinal, Infectious And Skin Diseases
Description
Therapeutic Drug Monitoring (TDM) of anti-infective agents consists of monitoring drug concentrations for dose optimization and for maximizing both clinical outcomes and pharmacological appropriateness, in patients with increasing average age, frailty, severity of illness, pharmacokinetic alterations, comorbidities, pathophysiological changes (body weight, chronic renal failure, hepatic impairment), immunocompromised status, and an increased risk of drug–drug interactions due to politherapy.The primary objective of TDM, across various biological samples, is to support clinicians by assessing therapeutic appropriateness through the measurement of concentrations in different samples, in order to ensure clinical efficacy, reduce adverse effects, and limit costs associated with inappropriate dosing. The study of biomarkers, including molecular markers, and omics also enables the characterization of the most correct immuno-microbiological response profiles.
Compensation
37,478 Euro
Job posting website
Number of positions
1
Maximum duration
24.0
Funding body
UniversitĂ di Torino
How to apply
Selection process
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View the original posting on the MUR website: Go to MUR website