Lactococcus lactis as a delivery system for protein replacement therapy in CDKL5 Deficiency Disorder

Scientific-Disciplinary Group

05/BIOS-06 - Physiology

Description

CDKL5 Deficiency Disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the CDKL5 gene, leading to early-onset epilepsy, severe intellectual disability, and motor and gastrointestinal impairments. No therapies are currently available to restore CDKL5 protein function. This project proposes an innovative strategy using the probiotic bacterium Lactococcus lactis to produce and deliver the therapeutic TATk-CDKL5 protein in vivo. Thanks to the TAT domain, the protein can cross cellular membranes and reach the brain. The project will evaluate protein expression, biodistribution, and therapeutic effects in the Cdkl5 knockout mouse model.

Job posting website

https://bandi.unibo.it/ricerca/incarichi-di-ricerca

Funding body

ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE

How to apply

Other

Selection process