Biocatalytic reactions for added-value applications in therapeutics and diagnostics (BRAVE)
Deadline: 23/06/2026
Scientific-Disciplinary Group
03/CHEM-07 - Medicinal, Toxicological, Nutraceutical-Food, Fermentation And Health And Wellbeing Products Chemistry
Description
The research activities will be dedicated to the biocatalyzed synthesis of chiral amines using transaminases and imine reductases. In particular, the enzymes of interest will be produced in recombinant form from the corresponding gene sequences. New variants of these biocatalysts can be obtained by protein engineering to improve their specificity/stereoselectivity. Engineered variants will also be obtained by fusion with protein tags to increase the solubility/stability of the enzymes, also facilitating their recovery at the end of the process. Innovative systems will also be developed for an efficient and sustainable use of the enzymes of interest, such as reaction systems involving the use of "green" solventsand systems with immobilized enzymes or "catch and release" systems to facilitate the recovery of the amine of interest from the reaction environment.
Compensation
28,495 Euro
Job posting website
Number of positions
1
Funding body
Consiglio Nazionale delle Ricerche - Istituto di Scienze e Tecnologie Chimiche
How to apply
Other
View the original posting on the MUR website: Go to MUR website