Uncovering the epigenetic and transcriptional control of innate immunity in leukemogenesis.
Deadline: 24/06/2026
Scientific-Disciplinary Group
06/MEDS-02 - Experimental Medicine, Pathophysiology And Clinical Pathology
Description
The project seeks to elucidate how transcriptional and epigenetic programs sustain immune (dys)regulation across myeloid leukemogenesis. It will syestmatically characterize the chromatin states of innate myeloid cells and their progenitors within the evolving bone marrow niche in AML, aiming to uncover mechanistic insights and identify regulatory nodes with therapeutic potential. Epigenetic drugs will be tested through pre-clinical trials using disease-relevant mouse models.Methodologically, the project will integrate a range of molecular and cellular approaches, including:• single-cell multi-omics analyses of hematopoietic and immune cells isolated from preclinical models of AML;• chromatin profiling of immune cell populations..
Compensation
22,500 Euro
Job posting website
https://www.unicampus.it/concorso/incarico-di-ricerca-ssd-meds-02-a-patologia-generale-ir-04_26/
Number of positions
1
Maximum duration
12.0
Funding body
Ministero dell’Università e della Ricerca
View the original posting on the MUR website: Go to MUR website