Characterization of the gut microbiota in patients undergoing fecal microbiota transplantation
Scientific-Disciplinary Group
03/CHEM-07 - Medicinal, Toxicological, Nutraceutical-Food, Fermentation And Health And Wellbeing Products Chemistry
Description
Fecal microbiota transplantation (FMT) is used to treat recurrent Clostridioides difficile infection, and its potential applications in other clinical settings are currently being evaluated. This project aims to characterise the gut microbiota of patients with various disorders undergoing FMT. Longitudinal faecal samples will be analysed using next-generation sequencing techniques, such as 16S rRNA amplicon sequencing and shotgun metagenomics, to achieve high taxonomic and functional resolution. Microbial strains of interest will be isolated using culturomics approaches and subjected to genome sequencing. All data will be integrated with host metadata to assess the role of the microbiota in the clinical response to FMT. Candidates should have a thorough understanding of human gut microbial ecology and solid skills in bioinformatics and biostatistical approaches applied to microbiome research.
Job posting website
Funding body
ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE
How to apply
Other
Selection process
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