Novel Catalytic Strategies for Organoboron Chemistry - 2026_IDR_DCMC_19
Scientific-Disciplinary Group
03/CHEM-06 - Chemical Foundations Of Technologies
Description
The project aims to develop innovative catalytic strategies for the sustainable synthesis of organoboron compounds (OBCs), which are fundamental in organic chemistry and crucial for the pharmaceutical and materials sectors. Since traditional methods based on carbanion chemistry are poorly sustainable, an efficient and eco-compatible approach for their synthesis and functionalization is proposed. Biocatalysis, a cornerstone of green chemistry, remains largely unexplored for OBCs due to the scarcity of natural enzymes capable of interacting with boron-containing substrates. The project therefore aims to engineer new-to-nature enzymatic transformations to form C–C and C–N bonds, exploiting the unique reactivity of OBCs. Both anionic and photo-induced radical mechanisms, mediated by photocatalysts or flavin-dependent enzymes, will be explored to create a versatile and sustainable biocatalytic platform for the stereoselective synthesis of chiral OBCs.
Job posting website
Number of positions
1
Funding body
Politecnico di Milano
Selection process
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View the original posting on the MUR website: Go to MUR website