Evaluating the antitumoral effects of small molecules on glioma and skin tumor cells
Posted on: 13/07/2026
Deadline: 12/08/2026
Scientific-Disciplinary Group
05/BIOS-04 - Comparative Anatomy, Cell Biology And Developmental Biology
Description
A major objective of this study is to selectively direct the cytotoxic activity of small molecules toward tumor cells to increase the specificity of these molecules. This underscores the need for tumor-selective delivery strategies to maximize therapeutic benefits while minimizing systemic toxicity. To achieve this goal and enable the development of an ADC, potential tumor associated surface markers will be screened. The expression of System Xc⁻, CD44, and selected members of the EGFR family will be analyzed in tumor cells (glioma and skin tumors) and compared with their normal counterparts. The potential for future opportunities exists with the identification of tumor-specific variants. To achieve this, specialized investigations are required to characterize these variants with high precision, such as RNA sequencing and long-read sequencing technologies.
Job posting website
Number of positions
1
Funding body
Università degli Studi Roma Tre
View the original posting on the MUR website: Go to MUR website