2026_IR_31_DIBIO Notice direct award n.1 Research Assignment entitled “Age-related RNA oxidation and ribosomal dysfunction in Parkinson’s disease vulnerable dopamine neurons”

- production and functional characterization of midbrain organoids differentiated from induced pluripotent stem cells carrying mutations in genes associated with Parkinson's disease;- transduction of viral vectors and transfection of RNA degraders into the organoids to evaluate the rescue of the pathological phenotype.