0D modelling of the interaction between coronary perfusion and ventricular function under physiological and pathological conditions.

Coronary perfusion supports the mechanical function of the heart. Alterations in coronary flow may reduce ventricular contractility and promote ischemia and heart failure. However, this link is difficult to quantify using standard clinical assessments alone.The project therefore aims to develop a 0D cardiovascular model of the coronary circulation, integrated into an existing systemic framework, to simulate the interaction between myocardial perfusion and ventricular contractility under physiological and pathological conditions. The model will include autoregulation and scenarios of increased cardiac demand, to investigate the possible vicious cycle between reduced coronary perfusion and deterioration of ventricular function.