Development of small compound inhibitors of the human NDC80 kinetochore complex

Position: Post-doctoral research appointment Institute: Uni. Trento
Posted on: 21/01/2026 Deadline: 11/02/2026

Scientific-Disciplinary Group

05/BIOS-08 - Molecular Biology

Description

This project focuses on small compounds that inhibit the ability of the human NDC80 kinetochore complex to attach the replicated chromosome pairs (sister chromatids) to the microtubules of the mitotic spindle. These compounds, along with future derivatives that are being developed in our laboratory, must be evaluated for molecular activity and therapeutic efficacy across a broad panel of cancer cell lines and

Number of positions

1

Funding body

Università degli Studi di Trento