Reprogrammed Monocytes Promote Cancer Cell Awakening and Metastatic Spread
Scientific-Disciplinary Group
06/MEDS-02 - Experimental Medicine, Pathophysiology And Clinical Pathology
Description
This project hypothesizes that THMs are key drivers of cancer immunoediting, linking chronic inflammation to tumor aggressiveness through metabolic rewiring, extracellular matrix remodeling, and soluble factor–mediated immune suppression. By integrating innovative mouse models, spatial multi-omics, tumor organoid systems, and patient-based analyses, the project aims to define the functional role of THMs across tumor progression and metastasis. The expected outcomes include identifying THMs as early biomarkers of disease progression and therapeutic resistance, and developing novel monocyte-targeting strategies to enhance the efficacy of cancer immunotherapy.
Compensation
28,456 Euro
Job posting website
https://www.univr.it/it/concorsi/contratti-e-assegni-di-ricerca/incarichi-post-doc/0/15785
Number of positions
1
Maximum duration
12.0
Funding body
Università degli Studi di Verona
How to apply
Other
Selection process
Click to expand
View the original posting on the MUR website: Go to MUR website