Melatonin-mediated modulation of mesenchymal stromal cells in scaffold supplemented with human platelet lysate for tissue regeneration
Posted on: 18/03/2026
Deadline: 07/04/2026
Scientific-Disciplinary Group
05/BIOS-12 - Human Anatomy
Description
Melatonin has attracted interest for its properties.It can regulate stem cell behavior by modulating redox balance,mitochondrial activity,inflammatory mediators & differentiation pathways.Recent studies highlight its incorporation into biomaterial scaffolds to improve biological performance.Scaffolds act as carriers for cells and bioactive factors,guiding tissue regeneration.Human platelet lysate rich in growth factors & cytokines,enhances proliferation,survival & reparative capacity of human mesenchymal stromal cells.This project investigates how melatonin modulates hMSC behavior within a scaffold enriched with hPL to promote a time-controlled therapeutic response during tissue healing.It will evaluate the effects of melatonin on hMSC viability & oxidative stress in a 3D microenvironment & whether melatonin modulates hPL bioactivity by influencing growth factor signaling through in vitro morphological,immunohistochemical & biochemical analyses
Number of positions
1
Funding body
Università degli studi di Brescia
How to apply
https://www.unibs.it/it/ateneo/amministrazione/concorsi/bandi-il-conferimento-di-incarichi-post-doc
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