Dissecting the mechanisms underlying human Purkinje neuron morphogenesis and dysfunction in rare ataxias using air–liquid interface cerebellar organoids

Position: Post-doctoral research appointment Institute: Uni. Trento
Posted on: 22/04/2026 Deadline: 12/05/2026

Scientific-Disciplinary Group

05/BIOS-08 - Molecular Biology

Description

This project is based on investigating the function of the T-dark gene LRCH2 in cerebellar morphogenesis, with a particular focus on Purkinje neurons, among the most complex cells in the nervous system. The project will involve the generation of LRCH2 knockout and mutant models using air–liquid interface cerebellar organoids to model LRCH2-dependent ataxia

Number of positions

1

Funding body

Università degli Studi di Trento