Tunneling nanotubes and extracellular vesicles as mediators of astrocyte—neuron communication in prion-like spreading of pathological tau
Deadline: 20/07/2026
Scientific-Disciplinary Group
05/BIOS-08 - Molecular Biology
Description
This project aims to investigate the integrated contribution of TNTs and EVs to astrocyte—neuron and microglia—neuron communication during tau pathology propagation. The study will examine how tau-induced cellular stress modulates TNT formation, the directionality of tan aggregate transfer, and the exchange of mitochondria between cells, distinguishing pathogenic spreading mechanisms from neuroprotective responses. The ultimate goal is to identify whether these communication pathways can be selectively targeted to limit pathological tau dissemination while preserving beneficial glial-mediated neuronal support
Compensation
39,683
Job posting website
Funding body
Università degli Studi Magna Graecia di Catanzaro
How to apply
Other
View the original posting on the MUR website: Go to MUR website