Pica Code IPD-2026-048 - RATIONAL DESIGN OF MULTI-TARGET K-RAS AND ADAM17 INHIBITORS AS POTENTIAL ANTICANCER DRUGS AND EVALUATION OF THEIR STRUCTURE-ACTIVITY RELATIONSHIPS

The research activity will consist in the design and development of dual inhibitors ofthe ADAM17 and K-RasG12C proteins as potential anti-tumour agents, by usingstructure-based in silico methods. An evaluation of the structure-activityrelationships on the targets of interest will also be carried out of the developedcompounds