Molecular mechanisms and therapeutic vulnerabilities underlying Richter transformation in chronic lymphocytic leukemia

The project aims to elucidate the molecular mechanisms underlying the transformation of chronic lymphocytic leukemia (CLL) into Richter syndrome (RS), with particular emphasis on NOTCHI signaling and the interactions between neoplastic B cells and the tumor microenvironment (TME). The researcher will be responsible for experimental activities aimed at characterizing tumor—TME interactions and investigating the functional contribution of key molecular determinants to disease transformation. The researcher will also contribute to the identification of therapeutic vulnerabilities through high-throughput drug screening, followed by the in vitro and in vivo validation of selected candidate compounds