Investigation of the biological and environmental bases of the risk for major psychiatric disorders, including mood disorders and psychosis, and of the biological pathways related to this.

The research program aims to investigate the biological and environmental determinants of risk formajor psychiatric disorders and the molecular pathways through which such risk translates into clinical phenotype. The approach will integrate genetic information, neuroimaging measures, environmental factors and clinical assessment, in order to characterize the mechanisms linking individual variability, brain circuit organization and symptom expression. Computational tools will then be developed on these data to stratify patients into biologically homogeneous subgroups and to identify molecular correlates informing treatment selection. The program forms part of the translational research activities in clinical psychiatry carried out within MNESYS Forward.