2026-IdrDip-05-medmol - Nuclear Signalling Compartmentalization in Skeletal Muscle Aging: the Role of Kinase/Phosphatase Imbalance

This project proposes the novel idea that the balancebetween nuclear kinases and phosphatases is crucial forskeletal muscle homeostasis during aging. To test thishypothesis, the candidate will use different techniques andnovel tools (e.g., pooled optical CRISPR -FRET screenings,nuclear-targeted biosensors, spatial proteomics of nuclei insingle fibers). The identification of new targets involved inage-related nuclear dysfunction and the conceptual ideathat reframes sarcopenia as a nuclear signalling disorder,will be important to advance the knowledge in the field ofaging.

Selection process

The application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: https://pica.cineca.it/unipv/tipologia/idr selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carried out on the basis of qualifications and possible interview (with test of knowledge of the foreign language) (see Art. 1 par. 1 Call for applications). The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: https://pica.cineca.it/unipv/tipologia/idrThe selections are open to candidates, Italian or foreigner, in possession, on the date of the deadline for submitting applications for the admission to the selection, of a master's degree or single-cycle, preferably in Biotechnology - LM-9 degree program or a degree in Biological Sciences (LM-6),degree obtained no more than six years previously are eligible to participate in the selection process. These degrees must be relevant to the subject of the research activity. Further specific assessable qualifications (see Art. 1 par. 1 Call for applications): PhD,preferably in a biological or biomedical field. PhD thesis and Master's degree final grade. Experience in cell culture techniques, particularly with C2C12 myogenic cells,cell transfection, and isolation of skeletal muscle fibers.Experience in FRET analysis, biochemical techniques for protein analysis, including electrophoresis and Western blotting, immunofluorescence, and fluorescence microscopy.Experience in investigating second messenger signaling pathways, particularly cyclic AMP (cAMP) and Ca²⁺. Experience in the study of the equilibrium between kinases and phosphatases and their functional microdomains

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