2026-IdrDip-06-medmol - Germline predisposition to the onset of Ph-negative myeloproliferative neoplasms

The projects has 3 main aims: 1)To evaluate the prevalence of germline mutations in DNA repair genes in MPN and their correlation with the clinical phenotype; 2) to explore in hematopoietic stem and progenitor cells how germline CHEK2 variants synergize with the classical MPN driver mutations in JAK2 to promote clonal expansion and disease manifestation; 3) to test whether familial surveillance is able to preemptively identify solid cancers and myeloid disorders in presymptomatic relatives carrying mutations in DNA repair genes.

Selection process

The application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: https://pica.cineca.it/unipv/tipologia/idr selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carried out on the basis of qualifications and possible interview (with test of knowledge of the foreign language) (see Art. 1 par. 1 Call for applications). The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: https://pica.cineca.it/unipv/tipologia/idrThe selections are open to candidates, Italian or foreigner, in possession, on the date of the deadline for submitting applications for the admission to the selection, of a master's degree or single-cycle, degree obtained no more than six years previously are eligible to participate in the selection process. These degrees must be relevant to the subject of the research activity. Further specific assessable qualifications (see Art. 1 par. 1 Call for applications):- Specialization in Hematology- Experience in clinical and translational research- Experience in the methodology of planning and conducting clinical and translational studies;- Proficiency in spoken and written English

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