Investigation of the microbiota-immune system-brain tumor axis inpreclinical glioma models

Research activity focus on investigating the interactions between the gut microbiota, the immune system, and glioma progression using preclinicalmouse models. Experimental procedures include fecal microbiota transplantation, pharmacological treatments, tumor growth monitoring, andassessment of neuroimmune responses. The project also involves cellular and molecular analyses through the isolation and characterization ofimmune cell populations, cell culture techniques, and functional cytotoxicity assays. In addition, bacterial extracellular vesicles and their role inmodulating anti-tumor immune responses are studied. Particular emphasis is placed on understanding the mechanisms underlying microbiota-braincommunication and the immune landscape of the tumor microenvironment.