Investigating the Muscle-specific Power of thyroid hormone to ACTivate body metabolism

The assignment is aimed at collaborating on the experimental activities envisaged by the IMPACT project, using genetically modified mouse models and primary cultures of muscle stem cells. Activities will include the characterization of the muscle phenotype under physiological and pathological conditions,the analysis of metabolic parameters and energy homeostasis, as well as the study of alterations associated with muscle atrophy. Molecular and cellular biology methodologies will also be used to evaluate metabolic adaptations and gene expression in response to the modulation of thyroid hormone action.