Modulation of the Kynurenine Pathway and Neurotransmitter Systems in the Kmo+/− Mouse Model Following Chronic Exposure to Cannabinoids

The project aims to characterize the effects of chronic exposure to THC and synthetic cannabinoids in the Kmo+/− mouse model. Potential alterations in the kynurenine pathway and different neurotransmitter systems will be assessed by HPLC analysis in selected brain regions. Neurochemical changes will be correlated with behavioral outcomes using specific behavioral tests. Biochemical and molecular analyses will complement the study to further elucidate the mechanisms underlying the response to cannabinoids.