Identification of Endothelial Antigens Induced by Mechanical Stimuli in Aortic Stenosis - 2026_IDR_DCMC_29

The researcher will be involved in the study of cellular response mechanisms to different mechanical stimuli, with the aim of identifying and characterizing antigens exposed by specific endothelial cell populations under physiological and pathological conditions.The experimental activity will focus on two types of human endothelial cells: Human Aortic Endothelial Cells (HAEC) and Human Cardiac Microvascular Endothelial Cells (HCMEC). The cells will be subjected to two different mechanical loading conditions:Normal pressure, aimed at simulating the mechanical interaction between the prosthetic valve and the patient's tissue through the application of static pressure.Shear stress, aimed at reproducing both physiological and pathological hemodynamic conditions through the application of a continuous flow regime with different shear stress levels to mimic physiological and pathological environments.

Selection process

In order to participate in the selection, please read the call ("bando") available at the following website: https://www.polimi.it/en/bandi-incarichidiricerca Oral test aimed at ascertaining candidates’ aptitude and suitability to carry out the research activity covered by the Fellowship, as well as at assessing their knowledge of English and/or other languages relevant to the research activities to be performed (up to 40 points) Relevance and pertinence of the publications, theses and scientific products attached to the research programme covered by the Fellowship (up to 30 points) Relevance and pertinence of previous research activities and work experience, if any, in relation to the research activity covered by the Fellowship (up to 15 points) Relevance and pertinence of their study programme to the research programme covered by the Fellowship (up to 15 points)

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