Neurophysiology of synaptic transmission in health neurologicaldisorders and neurodevelopmental disorders

The project focuses on the electrophysiological investigation of the pathophysiological mechanismsof synaptic transmission in neurological and neurodevelopmental epileptic disorders. The researchwill address the mechanisms disrupting the balance between excitatory and inhibitory transmission,with particular emphasis on GABAergic dysfunction and modulation of synaptic receptors. Thecandidate will independently design and perform experiments using cellular electrophysiologicaltechniques and will carry out electrophysiological and statistical data analysis and modelling. Theproject also includes critical interpretation of the results, preparation of scientific manuscripts inEnglish, and dissemination of findings, with the aim of identifying synaptic mechanisms andpotential therapeutic targets