Investigating the role of NEUral driven PlGF-NRP1 axis in shaping the vascular niche of recruited and self-renewing arterial MACrophages during aortic aneurysm (Finanziato dal Fondo Italiano per la Scienza FIS3 (FIS-2024-06736) CUP B53C25003640001

Aortic aneurysms are focal dilatations of the artery wall. Nervous and immune systems, in particular arterial macrophages, are crucial players in modulating vascular contractility. The aim of this research is to understand how nervous and immune systems interact during aortic aneurism progression and how they affect vascular function, in order to modulate immune response and counteract aortic aneurysm progression. The candidate role will be to investigate functional interactions established between neurons, immune cells and the vasculature in aorta developing aneurysm.