Investigating the Muscle-specific Power of thyroid hormone to ACTivate body metabolism

The research program aims to study the molecular and metabolic mechanisms through which thyroid hormones regulate skeletal muscle function and the body's energy homeostasis. Activities involve the use of genetically modified mouse modelsand in vitro cell systems, integrating molecular and cellular biology approaches, gene and protein expression analysis, metabolic pathway characterization, and mitochondrial function assessment. Furthermore, themetabolic adaptation mechanisms associated with alterations in thyroid hormone action and pathological conditions, with particular reference to muscle atrophy, will be explored.The integration of molecular, metabolic, and functional data will help clarify the role of muscle-specific thyroid action in regulating systemic metabolism and skeletal muscle adaptation.