Clinical-biological characterization and study of prognostic and predictive factors of response in myelodysplastic syndromes and acute myeloid leukemias.

The research program aims to study and characterize clinically and molecularly myelodysplastic syndromes and acute myeloid leukemias through the use of advanced sequencing technologies and the integration of clinical, hematological, cytogenetic, and molecular data.The goal is to identify new biomarkers and prognostic and predictive factors for treatment response, further exploring the relationships between molecular profiling, clinical course, and disease progression.Particular attention will be paid to the study of clonal evolution and molecular dynamics associated with disease progression and treatment response, in order to gain a deeper understanding of the biological mechanisms underlying leukemic progression and therapeutic resistance, including through longitudinal analysis of molecular profiles.